White SkinMedica TNS Advanced+ Serum bottle with gold trim against a light blue background.
Silver SkinMedica TNS Advanced+ Serum bottle beside curved serum swatches.
SkinMedica TNS Advanced+ Serum bottle on a clear display beside a product overview and an Allure award badge.
SkinMedica TNS Advanced+ Serum comparison photos of the side of a model's face labeled Before and After.
SkinMedica TNS Advanced+ Serum ingredient overview on a pale gold background.
Open SkinMedica TNS Advanced+ Serum pump and a serum swatch beside a study summary.

SkinMedica TNS® Advanced+ Serum

$295.00
Shipping calculated at checkout.
Size: 1.0 fl oz

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Growth Factor Serum
Advanced Skin Rejuvenation
Suited for:
All skin types
Target concerns:
Coarse wrinkles, sagging, uneven texture
Benefits:
Smooths wrinkles, firms, refines
When to use:
Morning and evening

DESCRIPTION

SkinMedica TNS® Advanced+ Serum – A next-generation growth factor serum powered by TNS®-MR and RENESSENSCE (RSC) Advanced to improve the appearance of coarse wrinkles, fine lines, sagging skin, tone, and texture while supporting a smoother, firmer, more youthful-looking complexion.

Provides advanced growth factor technology to support healthy skin function
Helps smooth visible coarse wrinkles and fine lines
Clinically proven to address the appearance of sagging skin
Supports improved skin tone, texture, firmness, and radiance
Colorless, fragrance-free, lightweight formula layers easily in any routine

Who benefits? Ideal for all skin types, especially mature, aging, texture-concerned, or firmness-focused skin, perfect for those seeking a high-performance treatment serum to support smoother, firmer, younger-looking skin over time.

  • Proven Wrinkle Results
  • Dual-Chamber Formula
  • Growth Factor Science
  • Every Skin Type
  • Firmer, Smoother Look
  • Morning And Evening

PRODUCT DETAILS

How to use

Apply in the morning and evening after cleansing and toning. Apply one pump from each side onto your hand, blend together, and apply to a clean, dry face. Apply to the entire face, and neck and chest if desired. Allow product to fully absorb before applying additional products in your regimen. Avoid getting in eyes; if contact occurs, rinse eyes thoroughly with water.

Ingredients

Aqua/Water/Eau, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera (Grape) Flower Cell Extract, Pyrus Malus (Apple) Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin
Best Sellers Rank: #66 of 227

Ranked by units sold, last 90 days

Ideal for these Concerns: Fine Lines & Wrinkles, Loss of Firmness, Skin Tightening
SHIPPING & RETURNS

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For eligibility and return instructions, please see our returns policy.

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    SkinMedica TNS® Advanced+ Serum

    White SkinMedica TNS Advanced+ Serum bottle with gold trim against a light blue background.

    How to use

    Apply in the morning and evening after cleansing and toning. Apply one pump from each side onto your hand, blend together, and apply to a clean, dry face. Apply to the entire face, and neck and chest if desired. Allow product to fully absorb before applying additional products in your regimen. Avoid getting in eyes; if contact occurs, rinse eyes thoroughly with water.

    Ingredients

    Aqua/Water/Eau, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera (Grape) Flower Cell Extract, Pyrus Malus (Apple) Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin
    The Age Rewinder
    Why You'll Love It
    A next-generation growth factor serum that visibly improves coarse wrinkles, sagging, tone, and texture.

    Scroll to see more product features

    • White SkinMedica TNS Advanced+ Serum bottle with gold trim against a light blue background.

      Proven Wrinkle Results

      Visibly improves coarse wrinkles, fine lines, and sagging skin with consistent twice-daily use.
    • Silver SkinMedica TNS Advanced+ Serum bottle beside curved serum swatches.

      Dual-Chamber Formula

      Two chambers blend at application so each dose delivers the complete technology fresh.
    • SkinMedica TNS Advanced+ Serum bottle on a clear display beside a product overview and an Allure award badge.

      Growth Factor Science

      TNS-MR and RENESSENSCE Advanced pair growth factors with green microalgae and peptides.
    • SkinMedica TNS Advanced+ Serum comparison photos of the side of a model's face labeled Before and After.

      Every Skin Type

      Suitable for all skin types and a natural next step for advancing aging concerns.
    • SkinMedica TNS Advanced+ Serum ingredient overview on a pale gold background.

      Firmer, Smoother Look

      Skin appears lifted, refined, and more even in tone with continued use.
    • Open SkinMedica TNS Advanced+ Serum pump and a serum swatch beside a study summary.

      Morning And Evening

      One pump from each side, blended and applied to a clean face and neck.
    Age-Defying Actives
    Key Ingredients

    Scroll to see more ingredients

    • Growth Factors
      Cellular Renewal
      Growth factors are signaling proteins that support the skin's natural renewal to improve the look of firmness and texture.
    • Peptide Complex
      Firming Support
      This peptide complex supports the look of firmness and helps soften the appearance of fine lines for smoother-looking skin.
    • Green Microalgae
      Marine Botanical
      Green microalgae is a marine botanical that helps support the look of firmness and a revitalized, healthier complexion.

    Need to Know

    Frequently Asked Questions

    What does this serum target?
    It's formulated to improve the appearance of coarse wrinkles, fine lines, uneven tone, and texture, and to visibly address sagging. With continued use it aims to reveal smoother, firmer, more youthful-looking skin.
    How do I use the dual-chamber design?
    Dispense one pump from each side onto your hand, blend the two formulas together, then apply to clean, dry skin morning and evening. You can extend it to the neck and chest, letting it absorb before other products.
    How is it different from TNS Recovery Complex?
    TNS Recovery Complex is a concentrated growth factor serum often used for renewal and post-procedure support, while TNS Advanced+ is a dual-chamber formula that adds a peptide complex, antioxidants, and botanicals. The two can even be layered together for those who want both.
    Can I use it with Recovery Complex?
    Yes. If you use both, apply TNS Recovery Complex first, then follow with TNS Advanced+ Serum. Together they layer growth factor and peptide benefits.
    What are growth factors and why are they in this serum?
    Growth factors are proteins that help signal skin to renew itself and support a healthier-looking surface. They're the technology this serum is best known for.
    How long until I notice results?
    Some people see visible improvements in as little as two weeks, though anti-aging benefits build with several weeks to months of consistent use. Sticking with it twice daily gives the best results.

    Product Comparison

    Find your best match

    Scroll horizontally to compare products.

    Product White SkinMedica TNS Advanced+ Serum bottle with gold trim against a light blue background. SkinMedica TNS® Advanced+ Serum This product White SkinMedica TNS Recovery Complex bottle with a gold rim against a light blue background. SkinMedica TNS Recovery Complex Alastin Skincare Restorative Skin Complex Alastin Skincare Restorative Skin Complex SkinCeuticals C E Ferulic (New Enhanced Formula) SkinCeuticals C E Ferulic (New Enhanced Formula)
    Suited for All skin types All skin types All skin types, aging skin All skin types, aging skin
    Target concerns Coarse wrinkles, sagging, uneven texture Fine lines, wrinkles, uneven tone Fine lines, dullness, loss of firmness Fine lines, dark spots, dullness
    Key ingredients Growth Factors, Peptides: Firms, Smooths. Growth Factors, Exosomes: Rejuvenates Skin. Peptides, Niacinamide, Ceramides: Restores Skin. Vitamin C, E, Ferulic + Carnosine: Antioxidant Defense.
    When to use Morning and evening Morning and evening Morning and evening Morning after cleansing
    Key benefits Smooths wrinkles, firms, refines Improves lines, tone, texture Firms, hydrates, supports collagen Antioxidant defense, brightens, firms
    Price
    $295.00
    $230.00
    $239.00
    $185.00
    Ratings
    4.9
    4.0
    4.7
    4.7
    Availability In stock Unavailable In stock In stock

    Reviews

    4.9

    Based on 10 reviews

    Showing 1–5 of 10 reviews

    Anthony M.

    I love this! Easy to use, and works so well. I have got many compliments.

    Jill M.

    Expensive but fast results! Only been using for about a month but I can already see an improvement in my skin

    Brian J.

    I’ve been using SkinMedica TNS Advanced+ Serum consistently, and it has become one of the few skincare products I truly feel is worth the investment. I have a dark complexion, and this serum has enhanced my skin without causing irritation or unevenness. My skin looks smoother, feels firmer, stays well hydrated, and has a healthy, radiant glow. I first started using it while living in Las Vegas, where the dry desert climate can be incredibly harsh on the skin. Even in that environment, this serum...

    Denise M.

    This is a product that produces results. The price tag is steep but it is worth it!

    Monica D.

    Simpler the best, tried and true. Works like a charm

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