Products with Acetyl HEXAPEPTIDE-8

Acetyl Hexapeptide-8, also known as Argireline, is a conditioning peptide. It helps soften the look of expression lines around the eyes and forehead, supporting a smoother, more relaxed-looking complexion.

Argireline across the ELLEMES range

Acetyl hexapeptide-8, better known by the trade name Argireline, is a six-amino-acid chain modeled on a fragment of a protein involved in muscle signaling. Applied topically it is used for the look of repeated expression movement, which is why it clusters in forehead, crow's-feet and lip-line formulas rather than in general moisturizers.

Six products here carry it, and they split along brand lines. Revision built Revox Line Relaxer around a peptide blend anchored by this ingredient. SkinCeuticals uses it in both P-TIOX and the P-TIOX Anti-Wrinkle Cream. SkinBetter Science includes it in InterFuse Intensive Treatment LINES, and Obagi in the SuzanObagiMD Super Antioxidant Serum.

Does acetyl hexapeptide-8 work like a neuromodulator?

No. It is a cosmetic ingredient that stays on the skin's surface, not an injectable, and it does not affect muscle function. What it can do is help expression lines look softer over weeks of consistent use, which makes it a common companion to in-office treatments rather than a substitute for them.

How to shop at ELLEMES

These are physician-dispensed formulas, purchased direct from each brand and stored properly on site. Ask us which one fits alongside the rest of your routine before you add a second peptide product.

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Featured Products with Acetyl HEXAPEPTIDE-8 Reviews

Revision Skincare Revox Line Relaxer
Revision Skincare Revox Line Relaxer
4.4 (106 reviews) 4.4 out of 5 stars based on 106 reviews
$99.00
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Featured review

“I purchased this product in July and have been using it twice a day since then. The container is still going strong now that it’s early September. I have noticed a difference on my forehead wrinkles....”

— Sara S.
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SkinCeuticals P-TIOX
SkinCeuticals P-TIOX
4.6 (146 reviews) 4.6 out of 5 stars based on 146 reviews
$150.00
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Featured review

“I lather this on my skin right before applying my moisturizer, and my skin definitely feels smoother and softer right afterwards. Although I can't say that there are drastic results so far, I'm looking forward to...”

— M
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Revision Skincare C+ Brightening Eye Complex
Revision Skincare C+ Brightening Eye Complex
4.6 (41 reviews) 4.6 out of 5 stars based on 41 reviews
$70.00
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Featured review

“This cream is moisturizing and helps with puffiness under my eye. The applicator is metal so it’s a little cold when you apply it. But it comes out nicely and absorbs into the skin well. I...”

— Sandy S.
Read all Revision Skincare C+ Brightening Eye Complex reviews →